Tuberculosis also known as Phthisis, Consumption, The Great white plague, The robber of youth, is highly infectious disease with an extended history of its occurrence among the Homo sapiens from ages, till now. Since ages it has consumed millions of life and continues to do so in the present times. After the discovery of the infectious agent, i.e., Mycobacterium tuberculosis by Robert Koch a German Bacteriologist, many advances in the medical science related to its pathogenesis, treatment options, prevention have taken into place. No doubt medical research have come long way ahead regarding the chemotherapy for the disease respectively, there still exists a huge challenge in the management of the disease and complete cure with a goal of complete eradication. The fact that the micro-organism rapidly adjusts against the chemotherapeutic agents administered to the infected body, as it multiplies rapidly and grows into an immune colonies against the existing chemotherapeutic agents known as resistant strains, it possess a high degree of challenge to cope with the infection taking in consideration of its high degree of transmissible nature. Therefore, it becomes pre-requisite to write on this review to develop an understanding of the management of tuberculosis which still haunts the medical science and health care practitioners. From normal strains of Mycobacterium tuberculosis, to (MDR) Multi-drug resistance strains, to XDR (Extended Drug Resistance) Tuberculosis and TDR (Total drug resistance) tuberculosis, the management of disease has come to a stage, Square one, i.e., right to an age where their used to exist no cure for the disease. The present review focuses on the history, description of TB, Chemotherapy, Diagnostics, Vaccines present and in trials, Herbal remedies and Current clinical trials happening across globe. India possess huge degree of morbidity and mortality related to the disease, topping the charts globally and acts as great burden on the population compared to other nations. The current review also focuses the clinical trials happening across India in our fight to completely eradicate the disease burden like it did for polio.
Loading....